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As e-cigarette use grows, more research needed on long-term effects of vaping By American Heart Association News As the number of young people using electronic nicotine delivery systems grows, so does evidence that e-cigarettes may be harmful to human health

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Studies have shown that long non-coding RNA (lncRNA), microRNA (miRNA) and DNA methylation, through various mechanisms to regulate the transcription of genes and proteins, and activate a series of molecular signal pathways to participate in the process of apoptosis [44,45,46](Table 1)

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