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Mezzrows marijuana network was legal until 1937 when, after aggressive lobbying on the part of Commissioner of the Bureau of Narcotics Harry Anslinger, Congress passed the Marijuana Tax Act, making cannabis illegal across the United States

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In addition to its stimulating effect on the nervous system, it is known to cause constriction of blood vessels

Riccardo Polosa , founder of CoEHAR and co-author of the review