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Serotonin promoted hepatocyte proliferation in vivo after APAP challenge As the former study showed that serotonin could promote the liver regeneration and hepatocyte proliferation after partial hepatectomy and hepatic ischemia/reperfusion injury 15,16 , we hypothesized that serotonin might also increase hepatocyte proliferation after the APAP overdose

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Simultaneously, Akt activation suppresses the ubiquitin proteasome system through inhibition of FoxO-mediated transcription of E3 ubiquitin ligases (MAFbx/Atrogin-1, MuRF1), which are responsible for protein degradation

Major organs, including the heart, liver, spleen, lung, and kidneys, were collected for histological analysis

For the enrichment analysis at dendrites and axons, the mean TNR fluorescence intensity was calculated for all image segments in concentric circles of increasing radii