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Recent studies have found that Src homolog and collagen homolog 3 (Shc3) are overexpressed in chemotherapy-resistant HCC and similarly activate this pathway, causing resistance to sorafenib and doxorubicin in HCC (168)

SCFAs activate GPCRs (GPR43/41) and inhibit histone deacetylases (HDAC), promoting regulatory T-cell (Treg) differentiation while suppressing Th17 cell polarization within the joint, thereby restoring immune homeostasis and reducing pro-inflammatory cytokine release

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They contain vitamin B12, which is safe in large quantities and is considered to help speed up the metabolic process and boost energy

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