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Proc Natl Acad Sci USA (2014) 111:E470615

NAD+ precursors : Inhibits degradation for sustained effects

Discordance Between Endocrine and Paracrine/Autocrine IGF-I An important example of metabolic and mitogenic consequences of an unbalanced endocrine versus autocrine/paracrine insulin-GH-IGF-axis comes from observations in children and adolescents with type 1 diabetes (Figure 5)