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Consequently, disrupting glutamine metabolism or the transsulfuration axis directly depletes GSH pools, severely impairing ROS clearance and amplifying oxidative DNA damage [57, 97]

10.1093/nar/gkab301 Nucleic Acids Res

Five-week-old female athymic nude mice were purchased from Envigo (Indianapolis, IN) and maintained in the institutional animal facilities approved by the American Association for Accreditation of Laboratory Animal Care