glutathione for elevated pyroglutamate Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen Impaired Glutathione Synthesis in Neurodegeneration

Mendelian randomization has confirmed a significant association between PM2.5 exposure and increased genetic susceptibility to UC [240], Immigrant studies also indicate that individuals migrating from low-incidence to high-incidence areas have an elevated risk of IBD [241, 242], while high birth order ( 3), due to early exposure to infections, is associated with a reduced risk of IBD [243], These macro-epidemiological findings underscore the importance of the synergistic role of environmental changes and genetic background

Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

Cells 181, 969977

The process for reducing insulin resistance involves increasing glucose utilization and potentiating the insulin signalling pathway via phosphatidylinositol 3-kinase (PI-3 kinase) at the post-receptor level

Crystal structure of g-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis