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While long-term exposure increases the risk of lung diseases such as chronic obstructive pulmonary disease (COPD) and asthma, especially in adolescents, short-term exposure can cause airway inflammation, hyperreactivity, decreased pulmonary function, susceptibility to microbial infection, and exacerbation of existing lung diseases
In a large study of over 333 patients with diabetic neuropathy taking 3 g of ALCAR/day (the same dose used in this study), the rise in serum level was only around 50 % compared to baseline
This enhanced uptake, combined with the peptides extended half-life of 20-30 hours, allows for sustained receptor start and prolonged natural effects
Biodistribution studies showed preferential accumulation in the olfactory bulb and cerebrospinal fluid, with spread to striatum and substantia nigra, consistent with absorption along olfactory/trigeminal pathways and transit across the cribriform plate into CSF (Fig
