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(PubMed) Leung AM, Lamar A, He X, Braverman LE, Pearce EN

It has been clearly shown that patients who successfully quit smoking have decreased rates of PAD progression, critical limb ischemia, amputation, MI, and stroke, as well as increased long-term survival

Subsequently, hydride transfer from the covalent intermediate to the NAD(P) + cofactor results in the formation of a thioacyl intermediate (compare the modelled reaction intermediate depicted in Figure 9B)