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Mechanistic studies of neurodegenerative diseases, such as VaD and AD, have shown that pathological processes, including neuronal damage and synaptic loss, are strongly associated with ferroptosis (Adeniyi et al., 2023

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Plant Physiol 126:397410 Kusano T, Kim DW, Liu T, Berberich T (2015) Polyamine catabolism in plants

In situ immunofluorescence of NRF2 also indicated this protein is highly expressed and present in the nucleus of A549 cells, with lesser expression in the nucleus of H23 cells (representative results shown in Supplementary Fig

In conclusion, TNBC is an aggressive and heterogeneous tumor that requires more selective treatment, and the xCT/NRF2/ OSGIN1 axis is a novel specific target for the treatment of MSL/CL subtypes overexpressing SLC7A11 , which may be more effective than GSH depletion