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For example, the impact of BSA-AGE (BSA incubated for 12 weeks with glucose) on cell cultures of amniotic and embryonic origin (WISH and MRC-5 cell lines) and on placental villi explants were determined

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Interestingly, in one study, the authors used metformin, which activates AMPK and autophagy, and it was studied in diabetic patients to improve insulin sensitivity and lipid metabolism

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Here we aimed at clarifying ALGS pathophysiology and understand the role of non-parenchymal liver cells in determining disease phenotype