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Oestrogens, such as oestradiol, are thought to be important in maintaining bone mass in women, and are thought to act by inhibiting paracrine factors that promote bone resorption (see below)

For example, PARP1 binds a DNA single strand break, then utilizes NAD + to ADP-ribosylate macromolecules in the vicinity, a signal for recruitment of DNA repair machinery 6

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