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Previous work with peptide arrays suggested that glutamic acid at P 0 of the TRAF6 binding motif of CD40 cannot be replaced by any other amino acid, including glutamine, without the loss of affinity towards TRAF6 58

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4.4 Type 2 diabetes mellitus (T2DM) T2DM is a significant comorbidity in PD, with shared pathogenic features including: Insulin resistance in the CNS

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