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CKD inflammation is driven by contributors such as reactive oxygen species (ROS) production, heightened immune system activity, and gut microbiota disruptions

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Campbell (CRUK Scotland Institute) for their scientific discussions and input in the revisions of this work

The apparent increase in Ca 2+ levels prompted investigations into the use of Ca 2+ -channel blockers, particularly drugs that block L-type voltage-gated Ca 2+ -channels, as potential treatments [23, 24]

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