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During the progression stage, H 2 O 2 is involved in the epithelial-to-mesenchymal transition (EMT) required for metastatic spread and the protumorigenic activity of tumor-associated macrophages, which participate in the formation of the tumor microenvironment

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(SOUNDBITE OF FLO SONG, "SUMMERTIME")

Tissues were then embedded in paraffin wax, sectioned at 3 m and stained with hematoxylin for 10 min then counterstained in eosin for 1 min followed by rapid rinsing in distilled water