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In their study, the combination caused cell death in Cal-33 oral cancer cells but not in HEK-293 normal cells

Such co-culture also helps to overcome the challenge of the effects of varying genetic background between cultures and, in addition, provides a chance to examine whether alterations are cell autonomous [95, 97, 102]

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10.3389/fphar.2023.1128872/full 112

SERT is associated with the transportation of serotonin into the presynaptic neurons from the synaptic cleft and along with 5-hydroxytryptamine transporter is involved in the termination of serotonergic signaling (Hensler 2010)