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10.1016/j.biomaterials.2023.122049 67 KuttippurathuL.JuskeviciuteE.DippoldR

Glutathione : Strong antioxidant

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Repeated painful exposure or inadequate sedation can alter cortical development, increase pain sensitivity, and contribute to long-term behavioral and neurodevelopmental effects ( The EUROPAIN study demonstrated substantial variability among European neonatal intensive care units (NICUs), with frequent use of opioids and sedatives without appropriate pain assessment or clear indication, a practice associated with hypotension, prolonged ventilation, and extended NICU stays ( In Italy, two decades of national surveys document gradual but incomplete progress