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This neuronal degeneration results in various symptoms, such as: Tremors Slowness of movement (bradykinesia) Balance problems Rigidity in the legs, arms, or body Psychiatric disorders Loss of facial expression The reasons an individual may develop Parkinsons disease are not fully understood, but it is believed to involve several factors: oxidative stress (damage from harmful molecules), cell death, inflammation in the brain, problems with energy production in cells, changes in gene activity, and the buildup of harmful proteins

Neuroscience 271:160169 Qin C, Yang S, Chu YH, Zhang H, Pang XW, Chen L, Zhou LQ, Chen M, Tian DS, Wang W (2022) Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions