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Moreover, various drugs and interventions, including natural compounds, enzymes from animal or plant sources [246,247,248,249,250,251,252], microbiota and derivatives [253,254,255], endogenous steroids [256, 257], and exercise [258], have been implicated in modulating the IGF pathway and potentially improving pathology and cognitive function in animal models of AD

(2) Plasma-membrane lipid bilayer: ROS attacks membrane PUFAs, driving lipid peroxidation and generating cytotoxic aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which compromise membrane integrity and fluidity and impair motility/fertilization-related functions

Expression levels of C

AM and JF conducted the experiments

MRI is the standard neuroimaging technique used to measure brain injury and a study by N Bhroin et al