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[23] [24] The MHRA advises testing for B12 deficiency if symptoms or signs develop in patients taking metformin, and considering periodic monitoring in those at risk

Always consult with your healthcare provider before starting any new supplement, especially if you have genetic mutations like MTHFR or COMT, or if you are taking medications that may interact with B12 absorption

They regulate gene expression, mitochondrial biogenesis, autophagy, and inflammation

Record all handling procedures, including reconstitution volume, date, and storage conditions, in your laboratory notebook for future reference and reproducibility