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It is highly addictive and withdrawal symptoms may be severe (but rarely fatal in adults)

Demystifying brain penetration in central nervous system drug discovery

The rats were euthanized, and tissue samples (brain, heart, kidneys, liver, spleen, lung, stomach, intestine, muscle, grease, ovaries, womb, testicles, and thymus) were collected at 3 min, 10 min, 1 h, and 24 h after administration (three males and three females at each time point)

Monthly cycles: Some protocols run 4-6 weeks on, then take breaks

It resists degradation for much longer than the acetate version, making it more robust for longer-term experiments or situations where refrigeration might be inconsistent