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de Groot PM, Arevalo O, Shah K, Strange CD, Shroff GS, Ahuja J, Truong MT , de Groot JF, Vlahos I

Protection against oxidative damage by iron chelators: effect of lipophilic analogues and prodrugs of N,N-bis(3,4,5- trimethoxybenzyl)ethylenediamine-N,N-diacetic acid (OR10141)

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Acting as inhibitors of the eukaryotic translation initiation factor 4A (eIF4A), an RNA helicase (106), silvestrol and rocaglamide bind eIF4A and lock it onto purine-rich sequences in the 5-untranslated region (UTR) of certain mRNAs, leading to translation inhibition (107, 112) ( Figure 1B )