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Many studies are pre-clinical (animal models) or small human trials making it harder to generalize to broad populations, especially those with complex sleep disorders such as sleep apnea or chronic insomnia

Moreover, a greater proportion of participants on retatrutide 8 and 12 mg (7782%) achieved an HbA1c 6.5% compared to placebo (5%) and dulaglutide 1.5 mg (43%)