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Differences in metabolic characteristics between naive and activated DCs were identified, and pathway-enrichment analysis revealed three significantly altered pathways, including the TCA cycle, -linolenic acid metabolism, and valine, leucine, and isoleucine degradation (110)

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On the other hand, epigenetic pathways may mediate the long-term increases in depression risk associated with unfavorable life events, as well as provide a mechanistic foundation for integrating genetic and environmental components (29)

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