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Indeed, a plethora of studies suggest a putative causal connection between ferroptosis and the pathophysiological processes underlying many conditions and diseases, including cancer, neurodegeneration, I/R-induced tissue injury, acute kidney damage, and hematologic diseases (Fig

Inhibition of IDO1 with shRNAs or IDO1 inhibitors increased ROS levels and produced significant growth inhibition only in cisplatin-resistant cells (D