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Deficiency of B12 can therefore lead to the destruction of the myelin sheaths, triggering a range of sensations: from tingling or numbness, especially in the hands and feet, to chronic pain and irreparable paralysis

Eur J Gen Pract (2006) 12(4):16973.10.1080/14017430601049449 24 Sanz-CuestaTGonzalez-EscobarPRiesgo-FuertesRGarrido-ElustondoSdel Cura-GonzalezIMartin-FernandezJet alOral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (project OB12)