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For instance, Clostridium butyricum TO-A, particularly when co-administered with butyrate, has been shown to lower both the transcriptional and translational levels of TLR4 in HT-29 intestinal epithelial cells (263)

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This observation may result from post-translational modifications (PTMs) of kallistatin, or alternatively, from subtle differences that were undetectable due to the small sample size used in the WB analysis

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For tendon, ligament, and joint repair, subcutaneous injection near the target tissue produces significantly stronger local effects than oral administration