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To address the highlighted clinical problems in skin malignancies, more information regarding single-as well as combined therapy methods based on verified basic, translational, and clinical research are still desired

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Tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying

This ultimately impairs IVD biomechanical properties, subsequently leading to structural alterations and development of discogenic LBP, as well as more severe sequelae, including disc herniation, spinal instability, and stenosis with serious neurological consequences (Roberts et al., 2006)

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