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Consequently, H 2 S has been shown to have a greater effect in the mesenteric arteries than the aorta.46 Hydrogen sulfide also causes relaxation via a muscarinic cholinergic-dependent pathway and may stop the conversion of angiotensin I to II.56 Hydrogen sulfide is implicated in septic shock, during which the endothelium produces H 2 S in response to cytokine- or inflammatory-mediated overstimulation.56,57 The role of H 2 S in CPB is unexplored and should be an area of future research

Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism

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