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There has been a long debate about the relative importance of the different antioxidant systems in RBCs responsible for H 2 O 2 detoxification

Other Causes of High Homocysteine (Besides Nutrient Deficiencies) While deficiencies in B6, B9 (folate), B12, vitamin D, and omega-3s are major contributors to high homocysteine levels, other hidden factors might be involved, such as: Genetics (MTHFR Mutation) Variants in the MTHFR gene affect how well your body converts folate into its active form (methylfolate)

Hypertens Res 43 , 582584 (2020)

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Unlike retinol, topical peptides such as GHK-Cu may work to upregulate both the breakdown and synthesis of collagen and other intercellular matrix components, thereby increasing collagen turnover [15]