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There are also potential risks of thyroid tumors in animal studies, although this hasnt been conclusively proven in humans

Additionally, broader clinical trials are necessary to evaluate the efficacy across a diverse patient group and safety considerations including potential drug-drug interactions and implications on patients with other medical conditions

Due to rapamycins therapeutic limitations, researchers have investigated other compounds that promote autophagy

For sorafenib used in first-line therapy, results of a randomized, placebo-controlled, phase III clinical trial investigating efficacy of sorafenib in 271 patients with HCC have been reported

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