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This has begun to influence international guidelines on the selection of patients for implantable cardioverter defibrillators (ICDs) that recommend lower thresholds for such devices in patients with LMNA, FLNC, PLN or RBM20 variants and other high-risk features beyond LVEF (Zeppenfeld et al., Reference Zeppenfeld, Tfelt-Hansen, de Riva, Winkel, Behr, Blom, Charron, Corrado, Dagres, de Chillou, Eckardt, Friede, Haugaa, Hocini, Lambiase, Marijon, Merino, Peichl, Priori, Reichlin, Schulz-Menger, Sticherling, Tzeis, Verstrael, Volterrani and Group2022)

Post centrifugation, 0.5-mL volume fractions were collected from top to bottom of the tube by careful pipetting

HPV infection has been shown to induce the expression of these checkpoint proteins, impairing the ability of T cells to mount an effective anti-tumor response

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Guerriero, E