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This biological foundation has been exploited to develop prodrug forms of PROTACs (Pro-PROTACs), aimed at mitigating the systemic toxicity associated with off-target PROTAC activity

doi: 10.1038/jcbfm.2013.30 125

Co-released ART&Dex in response to ROS effectively performs ROS clearance and M1 to M2 macrophage repolarization by inhibiting the HIF-1 /NF-B cascade

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