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Their advantageous properties, including low molecular weight, minimal immunogenicity, facile chemical synthesis, robust tissue penetration, and an expansive target scope, position them as compelling alternatives to antibodies for addressing the cardinal limitations of PROTACs, namely poor selectivity, off-target toxicity, and inadequate delivery efficiency (Fig

IGFBP-2 causes the inactivation of protein tyrosine phosphatase (RPTP-) by binding to the RPTP- receptor and subsequently inhibits the transcription of the tumor suppressor gene PTEN

Interestingly, mutations in crystallin genes are sometimes associated with microcornea

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For this reason, healthcare providers across North America, Europe, and Australia frequently prescribe it