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Once the tumour became arrested in the palbociclib-treated group, mice were further randomized to receive either RSL3 (50 mg kg 1 , two times per week for 2 weeks) or the vehicle, resulting in four experimental groups: vehicle, RSL3, palbociclib and palbociclib + RSL3

Quantification of MGO levels in smokeless tobacco (SLT) products MGO levels in the SLT extracts were quantified using a sandwich enzyme-linked immunosorbent assay (ELISA) kit (Bioassay Technology Laboratory, UK