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These mechanisms are observed under controlled in vitro and in vivo laboratory conditions

For example, one commenter suggested excluding drugs that are the primary therapy and exceed a cost threshold that aligns with the drug's cost relative to the total C-APC claim cost from comprehensive packaging

IGF-1 is synthesized primarily in the liver and various peripheral tissues in response to growth hormone signalling and exerts its biological effects through binding to the IGF-1 receptor, a transmembrane tyrosine kinase receptor