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Description

Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria)

[371] Given the limited applicability of the trials' exclusion criteria to many RP patients, it's unlikely that future trials will include such individuals

In summary, GW501516, a PPAR-beta/delta agonist, appears to mitigate kidney inflammation downstream of AT1r activation in a high-fructose diet-induced model