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Although the results are limited due to a very small number of studies and patients, an ongoing phase 2 TOP-CKD trial (NCT04258397) that aims to recruit 200 participants and will be completed by December 2024, will hopefully provide additional evidence of the efficacy of pirfenidone as treatment for kidney fibrosis

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12 Glutathione easily changes from the reduced (the active form) to the oxidized form, so the thought was that it did not remain in the reduced form during absorption from the digestive tract