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In the November 2011 final rule (76 FR 67808), in alignment with the statutory requirement at section 1899(b)(2)(D) of the Act, CMS established that, at a minimum, an ACO shall have at least 5,000 such beneficiaries assigned to it to be eligible to participate in the Shared Savings Program under 425.110

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Supplementary Materials Data Availability Statement The authors declare that all data supporting the findings of this study are provided in the Manuscript and its Supplementary Information/Source Data files

however, the size and complexity of cortical and hippocampal astrocytes decrease substantially with age 134,135,183

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