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More recent studies suggest that the blood concentration of trimethylamine N-oxide (TMAO), generated from trimethylamine-containing nutrients like dietary choline, rather than that of choline, might influence the risk of cardiovascular events (see Safety)

Lactate was also found to signal through specific G-protein coupled receptors expressed in neurons and glial cells, suggesting a possible role in neurotransmission, neurovascular coupling, and brain energy metabolism (Morland et al., 2015)

Moreover, a substantial methodological heterogeneity, including inconsistent protocols, lack of blinding, and unclear randomisation, limits the robustness of the conclusions

More recently, a randomized, double-blind, 24-week cross-over trial in 63 adults suffering from migraines found that 500 mg/day of magnesium oxide was equally effective as sodium valproate for reducing the migraine frequency and duration over the eight-week treatment period (194)

As the disease progresses, engaging in structured physical therapy or exercise may be an effective way of maintaining balance and avoiding falls