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These findings support the proposed rationale of combinatorial regimens of CICD modulation and existing strategies in lung cancer

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-smallcell lung cancer in preclinical models

For example, mesenchymal stem cell therapy can migrate to damaged brain tissue through the homing effect and paracrine neuroprotective factors to alleviate CI/RI (Rust et al., 2024)

This complex phosphorylates RIPK3, which subsequently recruits the executive protein MLKL, forming Complex IIb, commonly referred to as necrosome [56, 57]