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Expression of RCC1 (a GEF for Ran) reversed the reduction in RanGTP/total Ran ratio induced by Sema4D treatment in MCF7 and LNCaP cells (Fig

In both models it occupies the Phe145-Trp158-Arg177 region which has previously been shown to be the binding site of glutathione disulfide during the redox reaction of glutathione [35]

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Kusaczuk M, Tyszka N, Kretowski R, Cechowska-Pasko M

In the current study, our results suggest that GPX1 protects against peroxynitrite-induced SGNs damage by suppressing ROS accumulation in SGNs