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Additionally, Tsc2 -/- Atf4 -/- MEFs showed a decrease in cystine uptake when compared to parental Tsc2 -/- MEFs, which could be rescued with re-expression of ATF4 (Figure 6L)

This improvement was accompanied by an increase in DAT binding on DaTscan imaging, suggesting a potential neuroprotective effect and enhancement of dopaminergic function