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In a pilot trial, DFP orally administered 15 mg/kg twice daily showed reduced iron deposition in the globus pallidus in patients with pantothenate kinase-associated neurodegeneration (PKAN), a rare disease characterized by neurodegeneration with brain iron accumulation (NBIA) (Uzungil et al., 2022)

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Quantification revealed that CI-CIV substantially returned to normal in the Mito and P-Mito groups and that the adjustment in CIV expression in the P-Mito group was more significant than in the Mito group (Fig

Zheng, Y