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Sirtuins in neurodegenerative diseases: an update on potential mechanisms

Coviello, A M

Pyridoxamine (PM) inhibits the oxidative degradation step after Amadori products are formed by binding metal ions to generate complexes, reducing AGE production (105)

Selective antagonists of the cysteinyl leukotriene 1 receptor (CysLT 1 ) have proven helpful in patients with asthma and studies of these drugs in COPD patients are now underway