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doi: 10.1007/978-3-319-15126-7_17 43 El AgouzaIMEissaSSEl HouseiniMMEl-NasharDEAbd El HameedOM

In vitro analysis of human erythroid progenitor cells that underwent shRNA knockdown of HDAC1 or HDAC2 genes resulted in increased levels of -globin but without altering cellular proliferation of the cell cycle phase

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In extreme cases, patients may develop corneal and conjunctival damage, filamentary keratitis, or even ulcerationcomplications that can progress to vision loss if left untreated