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Overall, we most commonly predicted CATs sequences that localise to the cytoplasm (24 sequences), but also the mitochondria (2 sequences), nucleus, cell membrane and extracellular space (Fig

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While multiple published studies have drawn relationships between these SNPs and a wide variety of diseases, the American College of Medical Genetics has issued an official Practice Guideline recommending against testing or reporting on these two variants, citing "Recent meta-analyses have disproven an association between hyperhomocysteinemia and risk for coronary heart disease and between MTHFR polymorphism status and risk for venous thromboembolism

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