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While the revised guidance stated that CMS will compare the per unit rebate amount to the alternative per unit rebate amount, as described at 428.204, we proposed that CMS will compare the total rebate amount calculated in at 428.201(a) to the alternative total rebate amount, which we believe is consistent with the existing regulations for new formulations at 447.509(a)(4), as explained in the CY 2025 PFS proposed rule (89 FR 61972)

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It does not matter if a supplement contains 500mg of an ingredient if 490mg is destroyed during digestion