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CNS Neurol Disord Drug Targets 2018, 16 (10), 11201126

doi: 10.3389/famrs.2025.1525965 Received 11 November 2024 Accepted 07 March 2025 Published 31 March 2025 Corrected 08 April 2026 Volume 3 - 2025 Edited by Jos Luis Ros-Santaella, Czech University of Life Sciences Prague, Czechia Reviewed by Lola Brookes, National Centre for the Replacement Refinement and Reduction of Animals in Research, United Kingdom Ruth Marcec-Greaves, Lincoln Childrens Zoo, United States Updates Copyright 2025 Howard, Byrne, OBrien, Hobbs and Silla

Pathogenic genetic variants in NAD-synthesis enzymes lead to NAD + deficiency 14

Of note, all 3 of patients with ELF 13.0 was associated with a very high risk of developing LRE and these patients should be subject to enhanced follow up

Although not yet fully elucidated, this hypothesis is consistent with the clinical course observed in certain cases of long-term bruising following the use of dense liquid-form PCL scaffolds