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In CNS-relevant models, melanocortin receptor activation is used to probe appetite suppression and neuroendocrine arousal circuitry, including receptor desensitization dynamics in time-course assays

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Accurate differentiation between NAFLD subtypesincluding NAFL, NASH, and fibrosiscontinues to rely heavily on histopathological analysis, constraining epidemiological stratification and longitudinal assessments [103, 104]